Endocrine Abstracts

We report a rare case of propylthiouracil (PTU) induced ANCA-associated-vasculitis (AAV). This young lady with recurrent thyrotoxicosis and positive Thyroid peroxidase and TSH receptor antibodies since 2004 was treated with Carbimazole but was changed to PTU 100 mg daily during pregnancy in 2012.She was admitted to our hospital in January 2015 with sore throat, feeling unwell and neutropenia 1.2 (normal range (NR): 1.6–7.5) 10×9/l. Thyroid func...

A 44-year-old gentleman with history of intravenous drug abuse, was referred for new onset hyperthyroidism. He was diagnosed with hepatitis C a year prior to presentation. Treatment included pegylated-interferon (IFN-α) 100 μg weekly and Ribavirin 1 g daily. He had early viral response at week 4 of treatment with viral load of <30 IU/ml from 24 089 IU/ml. At week 8, patient complained of lethargy. He was tachycardic, but had no goitre or thyroid eye disease. Thyr...

A 48 year-old lady was referred to Endocrinology clinic in November 2016 with symptoms of tiredness and lethargy for two months. Routine bloods were unremarkable, apart from an incidental finding of raised Vitamin D:258 nmol/l(NR: 50–150). She had depression and was otherwise fit & well. She was on Citalopram and combined oral contraceptive pill (Microgynon). She denied any excessive sun exposure. She didn’t drink any milk, only drank orange juice. She took multi...

An 88 year-old male was referred to Endocrine Clinic with abnormal thyroid function test (TFT); free T4:fT4: 36.9pmol/L (NR:11-23) and a normal TSH:2.51mU/L (NR:0.35-5). Atrial Fibrilation was diagnosed recently and was on Apixiban and Bisoprolol. He had history of prostate cancer, hypertension, oesophagitis, cervical spondylosis, splenectomy and CKD3. He felt well apart from slight heartburn. He was a retired motor engineer. He had no family history of thyroid disease and nev...

A 61-year-old female was referred after being found to be hypokalemic and hypomagnesemic on routine blood test by her GP. Her low potassium of 2.7 has been persisting in spite of treatment with Kay-Cee-L. She denies using laxatives, diuretics, or excess liquorice. She reports intermittent episodes of diarrhea and nocturnal cramps. On examination, she was noted to be hypertensive. A full hormonal profile including 5 HIAA, 24 h urine catecholamines and coeliac screen were negati...

Methods: We retrospectively reviewed the medical notes of 39 patients who received radioiodine treatment (RAI) for thyrotoxicosis from 2004 until February 2010. Only 5.1% of patients had history of partial thyroidectomy; patients with previous history of RAI for thyrotoxicosis were excluded. All patients received written information leaflet for RAI.Results: Thirty (76.9%) patients were females and the median age of diagnosis was 59.5 years. 97.4% were Ca...

Methods: We retrospectively reviewed the medical notes of 39 patients who received radioiodine treatment (RAI) for thyrotoxicosis from 2004 until February 2010.Results: Thirty (76.9%) patients were females and the median age of diagnosis was 59.5 years. 17.9% had positive family history of thyrotoxicosis; current smokers (31%), ex-smokers (18%); Graves’ disease (56.4%), Multinodular goitre (41%), and unspecified diagnosis (2.6%). 18% of patients had...

We present the case of a 74-year-old man who was admitted with a short history of confusion and reduced mobility. He had a raised serum corrected calcium (cCa) of >5 mmol/l, serum parathyroid hormone (PTH) of 1.9 pmol/l (range 1.6–6.8 pmol/l) and acute renal failure. He was rehydrated and given a dose of i.v. zoledronate. Two days later his serum cCa remained elevated (4.39 mmol/l) with persistently impaired renal function. He underwent dialysis and serum cCa improved...